Ship: Prototype Stalker-C: repair system, etc. Unless the twiddles on the 21.126 are enabled, in which case, that.
Generator: Gravitron Pulse-Wave
Shield: Microcorp HXS Class C or otherwise the highest available (namely B in 2.1)
Front Weapon: Laser, 6.0 damage output per frame, higher than Zica by .5
Rear Weapon: Rear Mega Pulse, 7.428 DPF, highest normally avail by -a lot-
Left Sidekick: Zica Supercharger, .7 DPF, highest sustained output non-attachment
Right Sidekick: BattleShip-Class Firebomb, 4.0 DPF
Special: Situational, usually Repulsor for Gyges, otherwise SDF Main Gun or whatever happens by, delay being what it is it doesn't seem to matter that much in terms of total damage output
This is what I always used for Suicide/LOTG normal unhacked Full Games in Tyrian 2.x - not counting things new in 2k (not that anything in 2k looks like it can replace any of the above.) Damage figures calculated from the game's own tables, this is basically The highest sustained output configuration you can assemble. Sometimes, like in... I think it was ep3 bonus... I'll switch to something with the invulnerability twiddle and go sit on a particularly durable target - do you know what RMP+Laser does to something you're sitting on? Heh. Oh, in passing, I'll also note a few of the winners for stuff not normally available in the Full Game: Poison Bombs 6.666DPF, NortShip Spreader 12.0DPF. For true insanity, hack NSS as both front and rear weapon; if memory serves, that should work... >;-D
ship: Stalker 21.126 (even without the twiddles, high armor is priceless in LOTG since shields down means death and Stalker C twiddles are suicide in most of the case) Front gun: Laser/mega pulse (IMO zica laser is better at lower level but by the time you get it you have enough gold to get a high level laser, high Zica laser doesn't take down several little ships fast enough and doesn't follow your ship) R gun: rear mega pulse (good spread and fairly good firepower but needs a good generator so I usually go with vulcan cannon since it rocks for such a low price and the energy cost isn't so high) Generator: Graviton (of course) Shield: hightest possible at time (shield is way more important than armor almost every hard time in LOTG needs full shield in order to survive) Left Sidekick: Compagnon ship gerund (plasma storm spoils the fun when fighting bosses) Right Sidekick: Battleship Class Firebomb (it fires in the same pattern than sonic wave giving me no regrets choosing the rear mega pulse and it can be thrown up ahead to damage some armored enemies) Special: Repulsor/ice blast (their slow recharge makes them just perfect for engage mode AND they doesn't use shields like the twiddles) , SDF maingun is as powerfull as my laser and it goes through enemies but if I wanted something like that I would have chosen the Plasma storm, and SDF animation is too long so in engage mode you can't use twiddles fast enough
Zica supercharger are really crap I think, not only it fires at a slower rate than a true zica but charged it only has the power of a Zica laser level 4 and you don't need more front firepower once you have a Zica laser or a laser.
And finaly my most important weapon: my mouse I just can't dodge enemies' bullets with the keybord, firepower is nothing if I can't dodge effectively